• J. Korean Med. Sci. · Apr 2014

    Case Reports

    A case of IgG4-related disease with bronchial asthma and chronic rhinosinusitis in Korea.

    • Young-Soo Lee, Hyo-Jeong Cho, Hye-Soo Yoo, Yoo-Sub Shin, and Hae-Sim Park.
    • Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
    • J. Korean Med. Sci. 2014 Apr 1; 29 (4): 599-603.

    AbstractIgG4-related disease (IgG4-RD) is characterized by a systemic involvement of tumor-like lesions with IgG4-positive plasmacytes. We experienced a case of IgG4-RD developed in a patient with bronchial asthma (BA) and chronic rhinosinusitis (CRS). A 55-yr-old female patient with BA and CRS complained of both eyes and neck swelling as well as a recurrent upper respiratory infection in recent 1 yr. The serum levels of IgG4, creatinine, and pancreatic enzymes were elevated. A biopsy of the submandibular gland showed an abundant infiltration of IgG4-positive plasmacytes. Her symptoms remarkably improved after the treatment of a systemic steroid that has been maintained without recurrence. We report a rare case of IgG4-RD developed in a patient with BA and CRS.

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