• J. Korean Med. Sci. · May 2014

    Pertussis seroprevalence in korean adolescents and adults using anti-pertussis toxin immunoglobulin G.

    • Soo Young Lee, Seung Beom Han, E Young Bae, Jong-Hyun Kim, Jin Han Kang, Yeon-Joon Park, and Sang Hyuk Ma.
    • Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. ; Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    • J. Korean Med. Sci. 2014 May 1; 29 (5): 652-6.

    AbstractThis study was conducted to evaluate age-specific seroprevalence of pertussis in Korea and to formulate a strategy to prevent and reduce the incidence of pertussis. Residual serum samples of healthy adolescents and adults 11 yr of age or older were collected between July 2012 and December 2012, and anti-pertussis toxin (PT) IgG titers were measured using a commercial ELISA kit. We compared the mean anti-PT IgG titers and seroprevalence of pertussis of the six age groups: 11-20, 21-30, 31-40, 41-50, 51-60, and ≥ 61 yr. A total of 1,192 subjects were enrolled. The mean anti-PT IgG titer and pertussis seroprevalence were 35.53 ± 62.91 EU/mL and 41.4%, respectively. The mean anti-PT IgG titers and seroprevalence were not significantly different between the age groups. However, the seroprevalence in individuals 51 yr of age or older was significantly higher than in individuals younger than 51 yr (46.5% vs 39.1%, P = 0.017). Based on these results, a new pertussis prevention strategy is necessary for older adults.

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