• J. Korean Med. Sci. · Jun 2014

    Meta Analysis

    The effectiveness of recombinant human thyroid-stimulating hormone versus thyroid hormone withdrawal prior to radioiodine remnant ablation in thyroid cancer: a meta-analysis of randomized controlled trials.

    • Kyoungjune Pak, Gi Jeong Cheon, Keon Wook Kang, Seong-Jang Kim, In-Joo Kim, E Edmund Kim, Dong Soo Lee, and June-Key Chung.
    • Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea. ; Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea. ; Medical Research Institute, Pusan National University Hospital, Busan, Korea.
    • J. Korean Med. Sci. 2014 Jun 1; 29 (6): 811-7.

    AbstractWe evaluated the efficacy of recombinant human thyroid-stimulating hormone (rhTSH) versus thyroid hormone withdrawal (THW) prior to radioiodine remnant ablation (RRA) in thyroid cancer. A systematic search of MEDLINE, EMBASE, the Cochrane Library, and SCOPUS was performed. Randomized controlled trials that compared ablation success between rhTSH and THW at 6 to 12 months following RRA were included in this study. Six trials with a total of 1,660 patients were included. When ablation success was defined as a thyroglobulin (Tg) cutoff of 1 ng/mL (risk ratio, 0.99; 95% confidence interval, 0.96-1.03) or a Tg cutoff of 1 ng/mL plus imaging modality (RR 0.97; 0.90-1.05), the results of rhTSH and THW were similar. There were no significant differences when ablation success was defined as a Tg cutoff of 2 ng/mL (RR 1.03; 0.95-1.11) or a Tg cutoff of 2 ng/mL plus imaging modality (RR 1.02; 0.95-1.09). When a negative (131)I-whole body scan was used solely as the definition of ablation success, the effects of rhTSH and THW were not significantly different (RR 0.97; 0.93-1.02). Therefore, ablation success rates are comparable when RRA is prepared by either rhTSH or THW.

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