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- Lucas Topham, Stephanie Gregoire, HyungMo Kang, Mali Salmon-Divon, Elad Lax, Magali Millecamps, Moshe Szyf, and Laura Stone.
- Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
- Pain Rep. 2021 Jul 1; 6 (2): e944.
AbstractChronic pain is associated with persistent but reversible structural and functional changes in the prefrontal cortex (PFC). This stable yet malleable plasticity implicates epigenetic mechanisms, including DNA methylation, as a potential mediator of chronic pain-induced cortical pathology. We previously demonstrated that chronic oral administration of the methyl donor S-adenosyl methionine (SAM) attenuates long-term peripheral neuropathic pain and alters global frontal cortical DNA methylation. However, the specific genes and pathways associated with the resolution of chronic pain by SAM remain unexplored.Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.
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