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Anesthesia and analgesia · Oct 2009
Randomized Controlled Trial Comparative StudyA comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy.
- Harald Lenz, Leiv Sandvik, Erik Qvigstad, Carl Eivind Bjerkelund, and Johan Raeder.
- University of Oslo, Faculty Division Ullevaal University Hospital, Oslo, Norway. harald.lenz@medisin.uio.no
- Anesth. Analg. 2009 Oct 1;109(4):1279-83.
IntroductionIn this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain.MethodsNinety-one women received IV oxycodone or morphine before the end of laparoscopic hysterectomy and then continued with patient-controlled analgesia for 24 h postoperatively.ResultsThe accumulated oxycodone consumption was less (13.3 +/- 10.4 mg vs 22.0 +/- 13.1 mg, P = 0.001) than morphine. With oxycodone, the visual analog scale scores were significantly lower in the first hour postoperatively and sedation was less during the 24-h postoperative period, P = 0.006.ConclusionsOxycodone was more potent than morphine for visceral pain relief but not for sedation.
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