• Pak J Med Sci · May 2014

    Clinical pathologies of breast cancer in the elderly and youths and their prognosis.

    • Hong Ji, Ning Ai, Qinghuai Li, Kaili Zhang, and Wang Di.
    • Hong Ji, Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, P. R. China.
    • Pak J Med Sci. 2014 May 1; 30 (3): 535538535-8.

    ObjectiveTo explore the correlation between the clinical pathologies of breast cancer in the elderly and youths as well as their prognosis.MethodsTwo hundred and eighty breast cancer patients were divided into a youth group (<60, n=120) and an elderly group (≥60, n=160) according to the age. Their routine clinical pathological indices and immune indices were observed and determined, and the prognosis was observed after effective treatment.ResultsThe positive expression rates of p63, CK5/6, CK14 and CK17 in the elderly group were significantly higher than those of the youth group (P<0.05). The tumor-free survival rate of the youth group (95.8%) was significantly higher than that of the elderly group (84.4%) (P<0.05). Multivariate Logistic regression analysis showed that the positive expressions of p63 and estrogen receptor, age, and postoperative chemotherapy were the independent risk factors of tumor-free survival rate (P<0.05).ConclusionThe immunohistochemical typing characteristics of the elderly and youths were different, and the prognosis of young patients was better, being correlated with the typing.

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