• Xi Chen, Ying Xue Yang, Yu Lan Liu, Hua Tian Gan, and Zhong Hui Wen.
• Xi Chen, PhD, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.
• Pak J Med Sci. 2014 Sep 1; 30 (5): 1147-9.

AbstractHereditary angioedema is a rare autosomal dominant inherited disease which is characterized by an episodic, self-limiting increase in vascular permeability. Symptoms commonly involve in nonpitting, nonpruritic skin swellings. We present a case of hereditary angioedema. The patinets complained of a recurrent abdominal pain without accompanying skin swelling whose diagnosis was delayed nearly 20 years and accepted an unnecessary surgery. According to the decreased serum C1-inhibitor and C4 concentration, the patient was finally diagnosed with hereditary angioedema type I. After treatment with danazole, the patient reported a significant decrease in the frequency of attacks and the severity of pain. HAE is a rare cause of abdominal pain, however it needs to be taken as one of the differential diagnosis of various acute abdomens in order to avoid unnecessary surgeries.

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