• Asmaa Abdelhamid, Amanda Howe, Tim Stokes, Nadeem Qureshi, and Nick Steel.
• Population Health and Primary Care, Norwich Medical School, University of East Anglia, Norwich, UK.
• Br J Gen Pract. 2014 Nov 1; 64 (628): e719-27.

BackgroundClinical practice guidelines are widely used in primary care, yet are not always based on applicable research.AimTo explore primary care practitioners' views on the applicability to primary care patients of evidence underpinning National Institute for Health and Care Excellence (NICE) guideline recommendations.Design And SettingDelphi survey and focus groups in primary care, England, UK.MethodDelphi survey of the perceived applicability of 14 guideline recommendations rated before and after a description of their evidence base, followed by two focus groups.ResultsGPs significantly reduced scores for their perceived likelihood of pursuing recommendations after finding these were based on studies with low applicability to primary care, but maintained their scores for recommendations based on highly applicable research. GPs reported they were more likely to use guidelines where evidence was applicable to primary care, and less likely if the evidence base came from a secondary care population. Practitioners in the focus groups accepted that guideline developers would use the most relevant evidence available, but wanted clearer signposting of those recommendations particularly relevant for primary care patients. Their main need was for brief, clear, and accessible guidelines.ConclusionGuidelines should specify the extent to which the research evidence underpinning each recommendation is applicable to primary care. The relevance of guideline recommendations to primary care populations could be more explicitly considered at all three stages of guideline development: scoping and evidence synthesis, recommendation development, and publication. The relevant evidence base needs to be presented clearly and concisely, and in an easy to identify way.© British Journal of General Practice 2014.

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