• Medicina · Sep 2021

    Review

    Philadelphia-Negative MPN: A Molecular Journey, from Hematopoietic Stem Cell to Clinical Features.

    • Valentina Giai, Carolina Secreto, Roberto Freilone, and Patrizia Pregno.
    • Division of Hematology, Città della Salute e della Scienza, 10100 Turin, Italy.
    • Medicina (Kaunas). 2021 Sep 30; 57 (10).

    AbstractPhiladelphia negative Myeloproliferative Neoplasms (MPN) are a heterogeneous group of hematopoietic stem cell diseases. MPNs show different risk grades of thrombotic complications and acute myeloid leukemia evolution. In the last couple of decades, from JAK2 mutation detection in 2005 to the newer molecular trademarks studied through next generation sequencing, we are learning to approach MPNs from a deeper perspective. Here, we intend to elucidate the important factors affecting MPN clonal advantage and the reasons why some patients progress to more aggressive disease. Understanding these mechanisms is the key to developing new treatment approaches and targeted therapies for MPN patients.

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