• Hang Zhu, Hao Xue, Haotian Wang, Yundai Chen, Shanshan Zhou, Feng Tian, Shunying Hu, Jing Wang, Junjie Yang, and Tao Zhang.
• Department of Cardiology, General Hospital of PLA Beijing, China.
• Int J Clin Exp Med. 2015 Jan 1; 8 (3): 4038-44.

AimTo investigate the value of Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores for risk stratification and prognosis in female patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS).MethodsNon-elderly (<65 years) and elderly (≥65 years) female patients with NSTE-ACS (totally 869 cases) were enrolled in this study. The patients were further divided into low, intermediate and high-risk groups according to their GRACE and TIMI scores. Patients were followed up for 1 year to record the mortality and incidence of major adverse cardiac events (MACE). Differences in mortality and MACE incidence between the two scoring systems were compared by the area under the ROC curve.ResultsThe area under ROC curve corresponding to the mortality and MACE incidence in any period by the GRACE scoring system was significantly larger than the TIMI scoring system in the elderly patients (P<0.05). Mortality and MACE incidence increased in parallel with the scores. Risk ratio values of Cox regression analysis based on GRACE and TIMI scores were greater than 1 (P<0.001).ConclusionBoth GRACE and TIMI were adoptable in clinical risk stratification and prognosis of female patients with NSTE-ACS at different age groups. GRACE showed better accuracy than the TIMI scores.

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