• Dtsch. Med. Wochenschr. · Aug 1987

    [Effect of glycylpressin on pressure in esophageal varices in patients with liver cirrhosis and previous hemorrhaging varices].

    • M Staritz, A Rambow, and K H Meyer zum Büschenfelde.
    • Dtsch. Med. Wochenschr. 1987 Aug 21; 112 (34): 1292-5.

    AbstractIn 15 patients with the history of bleeding from esophageal varices, confirmed cirrhosis of the liver (Child A) and esophageal varices (grade II, 2; grade III, 11; and grade IV, 2 patients) esophageal intravariceal pressures were endoscopically measured before and 10 min after intravenous administration of 1 mg glycylpressin. Pressures fell in the patients without previous sclerotherapy from 21.8 +/- 2.8 to 19.0 +/- 1.9 mm Hg (not significant), in those previously sclerosed from 18.0 +/- 1.4 to 14.5 +/- 1.0 mm Hg (p less than 0.05). In two of the non-sclerosed patients and one after sclerotherapy no change of pressure was recorded. The results indicate that glycylpressin has a relatively minor and uncertain effect on esophageal intravariceal pressure. In view of the possible side effects of the drug the indications for its use should be carefully weighed.

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