• Tamas D Ambrisko, Johannes Schramel, Klaus Hopster, Sabine Kästner, and Yves Moens.
• Anaesthesiology and Perioperative Intensive Care Medicine, Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria. Electronic address: tambrisko@hotmail.com.
• Vet Anaesth Analg. 2017 Mar 1; 44 (2): 264-272.

ObjectiveTo examine changes in the distribution of ventilation and regional lung compliances in anaesthetized horses during the alveolar recruitment manoeuvre (ARM).Study DesignExperimental study in which a series of treatments were administered in a fixed order on one occasion.AnimalsFive adult Warmblood horses.MethodsAnimals were anaesthetized (xylazine, midazolam-ketamine, isoflurane), placed in dorsal recumbency and ventilated with 100% oxygen using peak inspiratory pressure (PIP) and positive end-expiratory pressure (PEEP) of 20 cmH2O and 0 cmH2O, respectively. Thoracic electrical impedance tomography (EIT), spirometry and routine anaesthesia monitoring were performed. At 90 minutes after induction of anaesthesia, PIP and PEEP were increased in steps of 5 cmH2O to 50 cmH2O and 30 cmH2O, respectively, and then decreased to baseline values. Each step lasted 10 minutes. Data were recorded and functional EIT images were created using three breaths at the end of each step. Arterial blood samples were analysed. Values for left-to-right and sternal-to-dorsal centre of ventilation (COV), lung compliances and Bohr dead space were calculated.ResultsDistribution of ventilation drifted leftward and dorsally during recruitment. Mean±standard deviation (SD) values at baseline and highest airway pressures, respectively, were 49.9±0.7% and 48.0±0.6% for left-to-right COV (p=0.009), and 46.3±2.0% and 54.6±2.0% for sternal-to-dorsal COV (p=0.0001). Compliance of dependent lung regions and PaO2 increased, whereas compliance of non-dependent lung regions decreased during ARM and then returned to baseline (p<0.001). Bohr dead space decreased after ARM (p=0.007). Interestingly, PaO2 correlated to the compliance of the dependent lung (r2=0.71, p<0.001).Conclusions And Clinical RelevanceThe proportion of tidal volume distributed to dependent and left lung regions increased during ARM, presumably as a result of opening atelectasis. Monitoring compliance of the dependent lung with EIT may substitute PaO2 measurements during ARM to identify an optimal PEEP.Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.

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