• Ari Z Klein, Arjun Magge, Karen O'Connor, Jesus Ivan Flores Amaro, Davy Weissenbacher, and Graciela Gonzalez Hernandez.
• Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
• J. Med. Internet Res. 2021 Jan 22; 23 (1): e25314.

BackgroundIn the United States, the rapidly evolving COVID-19 outbreak, the shortage of available testing, and the delay of test results present challenges for actively monitoring its spread based on testing alone.ObjectiveThe objective of this study was to develop, evaluate, and deploy an automatic natural language processing pipeline to collect user-generated Twitter data as a complementary resource for identifying potential cases of COVID-19 in the United States that are not based on testing and, thus, may not have been reported to the Centers for Disease Control and Prevention.MethodsBeginning January 23, 2020, we collected English tweets from the Twitter Streaming application programming interface that mention keywords related to COVID-19. We applied handwritten regular expressions to identify tweets indicating that the user potentially has been exposed to COVID-19. We automatically filtered out "reported speech" (eg, quotations, news headlines) from the tweets that matched the regular expressions, and two annotators annotated a random sample of 8976 tweets that are geo-tagged or have profile location metadata, distinguishing tweets that self-report potential cases of COVID-19 from those that do not. We used the annotated tweets to train and evaluate deep neural network classifiers based on bidirectional encoder representations from transformers (BERT). Finally, we deployed the automatic pipeline on more than 85 million unlabeled tweets that were continuously collected between March 1 and August 21, 2020.ResultsInterannotator agreement, based on dual annotations for 3644 (41%) of the 8976 tweets, was 0.77 (Cohen κ). A deep neural network classifier, based on a BERT model that was pretrained on tweets related to COVID-19, achieved an F1-score of 0.76 (precision=0.76, recall=0.76) for detecting tweets that self-report potential cases of COVID-19. Upon deploying our automatic pipeline, we identified 13,714 tweets that self-report potential cases of COVID-19 and have US state-level geolocations.ConclusionsWe have made the 13,714 tweets identified in this study, along with each tweet's time stamp and US state-level geolocation, publicly available to download. This data set presents the opportunity for future work to assess the utility of Twitter data as a complementary resource for tracking the spread of COVID-19.©Ari Z Klein, Arjun Magge, Karen O'Connor, Jesus Ivan Flores Amaro, Davy Weissenbacher, Graciela Gonzalez Hernandez. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 22.01.2021.

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