• Molly O Regelmann, Tamir Miloh, Ronen Arnon, Raffaella Morotti, Nanda Kerkar, and Robert Rapaport.
• Division of Pediatric Endocrinology and Diabetes, Mount Sinai School of Medicine, New York, New York 10029, USA.
• Thyroid. 2012 Apr 1; 22 (4): 437-9.

BackgroundHyperthyroidism has been associated with liver function abnormalities; however, cholestasis as the presenting feature of adolescent Graves' disease has not been previously reported.Patient SummaryThe patient was a 17-year-old girl who presented with severe cholestasis and was found to have Graves' disease. She also had a positive hepatitis A immunoglobulin M antibody but her clinical course, the liver histopathology, and her mildly elevated transaminases indicated that the acute hepatitis A infection was not dominant at the time of presentation with severe cholestasis. Other causes of cholestasis, including congestive heart failure, autoimmune hepatitis, and viral infection, were excluded. Treatment with methimazole resolved the hyperthyroidism, and the cholestasis improved, as well.ConclusionSevere cholestasis is a rare presenting feature of Graves' disease. With careful monitoring, methimazole can be used to treat the hyperthyroidism in the setting of cholestasis.

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