• Brian K Kwon, Wolfram Tetzlaff, Jonathan N Grauer, John Beiner, and Alexander R Vaccaro.
• Department of Orthopaedic Surgery, Thomas Jefferson University and The Rothman Institute, 719-1015 Chestnut Street, Philadelphia, PA 19107, USA. briankkwon@yahoo.ca
• Spine J. 2004 Jul 1; 4 (4): 451-64.

Background ContextThe past three decades have witnessed increasing interest in strategies to improve neurologic function after spinal cord injury. As progress is made in our understanding of the pathophysiologic events that occur after acute spinal cord injury, neuroprotective agents are being developed.PurposeClinicians who treat acute spinal cord injuries should have a basic understanding of the pathophysiologic processes that are initiated after the spinal cord has been injured. A familiarity with the literature on which the current use of methylprednisolone is based is also essential.Study Design/SettingLiterature review.MethodsLiterature review of animal data on pathophysiologic mechanisms, and of both animal and human trials of neuroprotective agents.ResultsThe mechanical forces imparted to the spinal cord cause primary damage to the neural tissue, but a complex cascade of pathophysiologic processes that imperil adjacent, initially spared tissue to secondary damage rapidly follows this. Attenuating this secondary damage with neuroprotective strategies requires an understanding of these pathophysiologic processes. Many researchers are investigating the role of such processes as ischemia, inflammation, ionic homeostasis and apoptotic cell death in the secondary injury cascade, with hopes of developing specific therapies to diminish their injurious effects. Beyond methylprednisolone, a number of other pharmacologic treatments have been investigated for the acute treatment of spinal cord injury, and even more are on the horizon as potential therapies.ConclusionsThis review summarizes some of the important pathophysiologic processes involved in secondary damage after spinal cord injury and discusses a number of pharmacologic therapies that have either been studied or have future potential for this devastating injury.

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