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Revue médicale suisse · Jan 2011
[Pediatrics. Fecal calprotectin in children: use and interpretation].
- J Ezri and A Nydegger.
- Unité de gastroentérologie et nutrition pédiatriques, Département médico-chirurgical de pédiatrie, CHUV, 1011 Lausanne.
- Rev Med Suisse. 2011 Jan 12; 7 (277): 69-70.
AbstractFecal calprotectin is a small protein released mainly by neutrophils. It is recognized as a reliable, easy and non-invasive biomarker of gastro-intestinal inflammation. Normal values vary with age, with higher cut-off values during the first year of life (<350 microg/g) than in children (<275 microg/g) or adults (<50 microg/g). Fecal calprotectin can be a useful tool in initial evaluation of recurrent abdominal pain, helping to distinguish between functional gastro-intestinal disorders, where it is normal, and inflammatory bowel disease (IBD). It is not a specific marker of IBD but is increased in other situations of gastro-intestinal inflammation. In patients with IBD, fecal calprotectin is used to monitor treatment response.
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