• Shahin Gaini, Mette Marie Relster, Court Pedersen, and Isik Somuncu Johansen.
• Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark; Infectious Diseases Division, Medical Department, National Hospital Faroe Islands, Tórshavn, Faroe Islands; Centre of Health Research and Department of Science and Technology, University of the Faroe Islands, Tórshavn, Faroe Islands. Electronic address: Lsshaga@Ls.fo.
• Int. J. Infect. Dis. 2019 Jan 1; 78: 1-7.

AimsEvaluating the use of sequential organ failure assessment (SOFA) ≥ 2 compared to quick SOFA (qSOFA) and to systemic inflammatory response syndrome (SIRS) in assessing 28-days mortality in medical patients with acute infection.MethodsIn total, 323 patients with verified infection were stratified in accordance to Sepsis-3. SOFA, qSOFA and SIRS were calculated using registered variables. Adverse outcome was death within 28-days of admission.ResultsIn total, 190 (59%) patients had a SOFA score≥2 and the overall in-hospital mortality was 21 (6%). Scores of SOFA and qSOFA were both significantly elevated in non-survivors. SOFA showed good accuracy (Area under the receiver operating characteristic (AUROC)=0.83, 95% CI, 0.76 - 0.90) for 28-days mortality compared with qSOFA (AUROC=0.67, 95% CI, 0.54 - 0.80) and SIRS (AUROC=0.62, 95% Cl 0.49 - 0.74). SOFA was≥2 in all patients who died, while qSOFA and SIRS was≥2 in 8 (38%) and 17 (81%) of the patients who died, respectively.ConclusionSOFA score≥2 was better than SIRS and qSOFA to predict mortality within 28-days of admission among patients with acute infectious disease.Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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