• N Kamel, L Metwally, N Gomaa, W A Sayed Ahmed, M Lotfi, and S Younis.
• Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
• Med Princ Pract. 2014 Jan 1; 23 (1): 29-33.

ObjectiveTo determine the frequency of primary cytomegalovirus (CMV) infection in pregnant Egyptian women using CMV IgG avidity testing.Subjects And MethodsA cross-sectional study was conducted at Suez Canal University Hospital, Ismailia, Egypt. A total of 546 pregnant women, presenting for routine antenatal screening, were tested for CMV IgG and IgM using a commercially available enzyme-linked immunosorbent assay (ELISA). Sera from CMV IgM-positive women were tested by CMV IgG avidity assay.ResultsAll the 546 pregnant women were seropositive for anti-CMV IgG. Of the 546 women, 40 (7.3%) were positive or equivocal for IgM antibodies. All sera from the 40 women (IgG+/IgM+) showed a high or intermediate CMV IgG avidity index. Of the 40 women, 23 (57.5%) were in the second or third trimesters of pregnancy and had their first-trimester blood retrieved, and the tested CMV IgG avidity assay showed a high avidity index.ConclusionWomen who were IgM positive had no primary CMV infection in the index pregnancy as evidenced by the high CMV IgG avidity testing.© 2013 S. Karger AG, Basel.

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