• Susmita Kashikar-Zuck, Adam Carle, Kimberly Barnett, Kenneth R Goldschneider, David D Sherry, Constance A Mara, Natoshia Cunningham, Jennifer Farrell, Jenna Tress, and Esi Morgan DeWitt.
• aDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA bDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA cJames M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA dPain Management Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA eDivision of Rheumatology, Children's Hospital Of Philadelphia, Philadelphia, PA, USA fDepartment of Psychology, University of North Texas, Denton, TX, USA gDivision of Rheumatology, Cincinnati Children's Hospital Medical Center, Medical Center, Cincinnati, OH, USA.
• Pain. 2016 Feb 1; 157 (2): 339-47.

AbstractThe Patient-Reported Outcomes Measurement Information System (PROMIS) initiative is a comprehensive strategy by the National Institutes of Health to support the development and validation of precise instruments to assess self-reported health domains across healthy and disease-specific populations. Much progress has been made in instrument development, but there remains a gap in the validation of PROMIS measures for pediatric chronic pain. The purpose of this study was to investigate the construct validity and responsiveness to change of 7 PROMIS domains for the assessment of children (ages: 8-18) with chronic pain--Pain Interference, Fatigue, Anxiety, Depression, Mobility, Upper Extremity Function, and Peer Relationships. The PROMIS measures were administered at the initial visit and 2 follow-up visits at an outpatient chronic pain clinic (CPC; N = 82) and at an intensive amplified musculoskeletal pain day-treatment program (N = 63). Aim 1 examined construct validity of PROMIS measures by comparing them with corresponding "legacy" measures administered as part of usual care in the CPC sample. Aim 2 examined sensitivity to change in both CPC and amplified musculoskeletal pain samples. Longitudinal growth models showed that PROMIS' Pain Interference, Anxiety, Depression, Mobility, Upper Extremity, and Peer Relationship measures and legacy instruments generally performed similarly with slightly steeper slopes of improvement in legacy measures. All 7 PROMIS domains showed responsiveness to change. Results offered initial support for the validity of PROMIS measures in pediatric chronic pain. Further validation with larger and more diverse pediatric pain samples and additional legacy measures would broaden the scope of use of PROMIS in clinical research.

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