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- Akira Kurishima, Mototaka Hayashi, Rin Shimozato, Ryo Isozaki, Tomoko Shioda, and Akira Iijima.
- Department of Pharmacy, Japan Community Health Care Organization Tokyo Shinjuku Medical Center, Japan.
- Intern. Med. 2022 May 1; 61 (9): 1457-1461.
AbstractValproic acid (VPA) and levetiracetam (LEV) are used in epilepsy treatment. However, their use to treat short-bowel syndrome has not been reported. We herein report a 68-year-old man who was hospitalized for symptomatic epilepsy following cerebral infarction. He had a history of superior mesenteric arterial occlusion, and only 30 cm of his jejunum was intact. VPA and LEV were administered, and good blood levels were achieved at clinical doses. This suggests that the gastrointestinal tract absorption of LEV and VPA is good even in patients with short-bowel syndrome and a 30-cm jejunum.
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