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- Mayumi Tamada, Shinji Ueno, Kako Watanabe, and MuramatsuShin-IchiSIDivision of Oriental Medicine, Center for Community Medicine, Jichi Medical University, Japan.Division of Neurology, Department of Medicine, Jichi Medical University, Japan..
- Division of Oriental Medicine, Center for Community Medicine, Jichi Medical University, Japan.
- Intern. Med. 2022 May 1; 61 (9): 143314381433-1438.
AbstractParasomnias are undesirable behaviors or experiences during sleep that manifest clinically as abnormal behavior, emotions, and nightmares. We herein report four elderly parasomnia patients who were successfully treated for abnormal nocturnal behaviors, including rapid eye movement (REM) sleep behavior disorders, with Keishikaryukotsuboreito (KRB), a Japanese traditional herbal medicine. KRB resolved nocturnal violent behaviors and sleep walking without any adverse effects. In one patient, occipital dominant spike-wave complexes induced by 3-Hz photic stimulation were reduced after KRB treatment, suggesting that KRB has inhibitory effects on brain irritability. KRB may represent a safe therapeutic option for treating parasomnias in the elderly.
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