• Internal medicine · May 2022

    Review Case Reports

    Clinical Characteristics and Predictors Related to the Progression of Multinodular Goiter Causing Tracheal Compression and Deviation: A Report of Two Cases and Review of the Literature.

    • Toshihiro Takamori, Shoichiro Izawa, Takahiro Fukuhara, Akemi Sato, Hitomi Ichikawa, Toru Motokura, Kazuhiro Yamamoto, and Tetsuya Fukuda.
    • Division of Clinical Laboratory, Tottori University Hospital, Japan.
    • Intern. Med. 2022 May 1; 61 (9): 1375-1381.

    AbstractWe describe the clinical course of two patients who developed tracheal compression and deviation by multinodular goiter (MNG). Case 1: A 66-year-old woman presented with thyroid swelling. Five years after the initial admission, she was diagnosed with hyperthyroidism by Graves' disease and increased bilateral thyroid lobes compressing the trachea. Thyroglobulin was elevated from 210 to 472 ng/mL. Case 2: A 52-year-old woman presented with thyroid swelling. Five years after the initial admission, the increased right lobe deviated the trachea and compressed the right recurrent laryngeal nerve. Thyroglobulin was elevated from 122 to 392 ng/mL. Two cases and literature review indicated that MNG with >50 mm, solid components, and extension to the mediastinum or paralarynx were risk factors of tracheal compression and deviation. Monitoring thyroglobulin elevation can help predict the clinical course.

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