• Internal medicine · May 2022

    Review Case Reports

    Locked-in Syndrome Due to Meningovascular Syphilis: A Case Report and Literature Review.

    • Yuki Yokota, Masaki Ishihara, Satoko Ninomiya, Kazutaka Mitsuke, Satoshi Kamei, and Hideto Nakajima.
    • Department of Neurology, Graduate School of Medicine, Nihon University School of Medicine, Japan.
    • Intern. Med. 2022 May 15; 61 (10): 159315981593-1598.

    AbstractWe herein report a 46-year-old man presenting with locked-in syndrome secondary to meningovascular syphilis. Brain magnetic resonance imaging (MRI) demonstrated multiple acute infarctions in the left ventromedial pons, right basis pontis, and left basal ganglia. His locked-in syndrome was hypothesized to have been caused by thrombosis of the small paramedian branches of the basilar artery due to syphilitic arteritis. This is a unique case of bilateral ventromedial pontine infarction caused by meningovascular syphilis that presented as locked-in syndrome. Meningovascular syphilis should be included in the differential diagnosis of uncommon stroke, particularly in young men.

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