• Shuichi Tange, Koji Uchino, Hirotoshi Kakiwaki, Hirobumi Suzuki, Shinzo Yamamoto, Yukiko Ito, Hiroyoshi Taniguchi, Harumi Shirai, Takeshi Suzuki, Haruna Onoyama, Sakae Nagaoka, Toshio Kumasaka, and Hideo Yoshida.
• Department of Gastroenterology, Japanese Red Cross Medical Center, Japan.
• Intern. Med. 2022 May 15; 61 (10): 1525-1529.

AbstractA 78-year-old woman presenting with severe acute liver failure was admitted to our hospital. On screening for the etiology of acute liver failure, it was diagnosed as being due to idiopathic hypereosinophilic syndrome (eosinophil count reported as 4766/μL; 33.8% of the white blood cells). Her medical history included marked eosinophilia, as observed six months prior to this admission. Corticosteroid therapy was initiated. During the clinical course, duodenal perforation occurred but was managed promptly by appropriate surgery. A liver biopsy, following the initiation of corticosteroid therapy, revealed degenerating hepatic cells with mild eosinophilic infiltration. With corticosteroid therapy, the liver function improved.

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