• Internal medicine · May 2022

    Case Reports

    Juvenile Hepatocellular Carcinoma in a Healthy Liver: A Case Report.

    • Sachiyo Onishi, Masahiro Tajika, Tsutomu Tanaka, Keisaku Yamada, Tomoyasu Kamiya, Seiji Natsume, Yasuhiro Shimizu, and Yasumasa Niwa.
    • Department of Endoscopy, Aichi Cancer Center Hospital, Japan.
    • Intern. Med. 2022 May 15; 61 (10): 153115361531-1536.

    AbstractPrimary hepatocellular carcinoma (HCC) in patients <30 years old is extremely rare. In younger patients, HCC develops against a background of persistent hepatitis B virus infection. We herein report a 23-year-old woman with HCC with all-negative hepatitis virus markers developing in an apparently healthy liver. Imaging studies showed a 50-mm hypervascular mass in segment 4 of the left liver lobe, compatible with HCC. The patient underwent surgical resection. A histological examination showed the presence of poorly differentiated HCC. The patient was diagnosed with HCC developing in a healthy liver. This is an extremely rare case of non-B non-C HCC.

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