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Case Reports
CV2/CRMP5-antibody-related Paraneoplastic Neurologic Syndrome Associated with Gastrointestinal Stromal Tumor.
- Hirofumi Fukushima, Tomoyoshi Shibuya, Takahito Awatsu, Taro Kurosawa, Keiichi Haga, Takashi Murakami, Nobuko Serizawa, Akio Mori, Mariko Hojo, Takashi Yao, Nobutaka Hattori, and Akihito Nagahara.
- Department of Gastroenterology, Juntendo University School of Medicine, Japan.
- Intern. Med. 2022 May 15; 61 (10): 1497-1501.
AbstractParaneoplastic neurological syndrome (PNS) is a heterogeneous group of neurological disorders caused by immune-mediated inflammatory mechanisms. We herein report a 77-year-old man with CV2/CRMP5-antibody-related PNS associated with a gastrointestinal stromal tumor (GIST). He was admitted for forgetfulness and delusional behavior. His neurological symptoms were subacute, and a whole-body examination revealed a gastric GIST. Serology showed CV2/collapsin response mediator protein (CRMP)-5 antibodies. Partial gastrectomy was performed for the GIST, and the neurological symptoms and serum CV2/CRMP5 antibodies disappeared. No relapse has occurred since the surgery. PNS should be considered in patients with subacute neurological disorders.
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