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- Kazi Rafiq, Yu-Yan Fan, Shamshad J Sherajee, Yoshimasa Takahashi, Junji Matsuura, Naoki Hase, Hirohito Mori, Daisuke Nakano, Hideki Kobara, Hirofumi Hitomi, Tsutomu Masaki, Hidenori Urata, and Akira Nishiyama.
- 1. Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
- Int J Med Sci. 2014 Jan 1; 11 (3): 222-5.
AbstractWe examined the effects of overexpressed human chymase on survival and activity in lipopolysaccharide (LPS)-treated mice. Human chymase transgenic (Tg) and wild-type C57BL/6 (WT) mice were treated with LPS (0.03, 0.1 and 0.3 mg/day; intraperitoneal) for 2 weeks. Treatment with 0.03 mg LPS did not affect survival in either WT or Tg mice. WT mice were not affected by 0.1 mg/day of LPS, whereas 25% of Tg mice died. Survival of mice treated with 0.3 mg/day of LPS was 87.5% and 0% in WT and Tg, respectively. LPS-induced increases in chymase activity in the heart and skin were significantly greater in Tg than WT mice. These data suggest a possible contribution of human chymase activation to LPS-induced mortality.
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