• Int J Med Sci · Jan 2014

    Glial scar formation occurs in the human brain after ischemic stroke.

    • Lijie Huang, Zhe-Bao Wu, Qichuan Zhuge, Weiming Zheng, Bei Shao, Brian Wang, Fen Sun, and Kunlin Jin.
    • 1. Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China ; 2. Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China.
    • Int J Med Sci. 2014 Jan 1; 11 (4): 344-8.

    AbstractReactive gliosis and glial scar formation have been evidenced in the animal model of ischemic stroke, but not in human ischemic brain. Here, we have found that GFAP, ED1 and chondroitin sulphate proteoglycans (CSPG) expression were significantly increased in the cortical peri-infarct regions after ischemic stroke, compared with adjacent normal tissues and control subjects. Double immunolabeling showed that GFAP-positive reactive astrocytes in the peri-infarct region expressed CSPG, but showed no overlap with ED1-positive activated microglia. Our findings suggest that reactive gliosis and glial scar formation as seen in animal models of stroke are reflective of what occurs in the human brain after an ischemic injury.

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