• Tsung-Hsien Lin, Shao-Yuan Chuang, Chun-Yuan Chu, Wen-Hsien Lee, Po-Chao Hsu, Ho-Ming Su, Yi-Heng Li, Ching-Chang Fang, Kuo-Yang Wang, Wei-Kung Tseng, Ai-Hsien Li, Kwo-Chang Ueng, I-Chang Hsieh, Lien-Chi Huang, Chiun-Hsiung Wang, Wen-Harn Pan, Hung-I Yeh, Chau-Chung Wu, Wei-Hsian Yin, and Jaw-Wen Chen.
• 1. Division of Cardiology, Department of Internal Medicine; Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; ; 2. Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
• Int J Med Sci. 2014 Jan 1; 11 (4): 381388381-8.

BackgroundPatients with chronic kidney disease (CKD) is a very high risk cardiovascular disease population and should be treated aggressively. We investigated lipid management in CKD patients with atherosclerosis in Taiwan.Methods3057 patients were enrolled in a multi-center study (T-SPARCLE). Lipid goal are defined as total cholesterol (TC) < 160mg/dl, low-density lipoprotein (LDL) <100 mg/dl, high-density lipoprotein (HDL) > 40 mg/dl in men, HDL > 50 mg/dl in women, non-HDL cholesterol < 130mg/dl, and triglyceride < 150 mg/dl.ResultsCompared with those without CKD (n=2239), patients with CKD (n=818) had more co-morbidities (hypertension, glucose intolerance, stroke and heart failure) and lower HDL but higher triglyceride levels. Overall 2168 (70.5%) patients received lipid-lowering agents. There was similar equivalent statin potency between CKD and non-CKD groups. The goal attainment is lower in HDL and TG in the CKD group as compared with non-CKD subjects (47.1 vs. 51.9% and 63.2 vs. 68.9% respectively, both p < 0.02). Analysis of sex and CKD interaction on goals attainment showed female CKD subjects had lower non-HDL and TG goals attainment compared with non-CKD males (both p < 0.019).ConclusionAlthough presenting with more comorbidities, the CKD population had suboptimal lipid goal attainment rate as compared with the non-CKD population. Further efforts may be required for better lipid control especially on the female CKD subjects.

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