• Kai Liu, Bai Ji, Wei Zhang, Songyang Liu, Yingchao Wang, and Yahui Liu.
• Department of Hepatobiliary and Pancreatic Surgery, the First Bethune Hospital, Jilin University, Jilin 130021, China.
• Int J Med Sci. 2014 Jan 1; 11 (9): 893896893-6.

ObjectiveThis retrospective study compared the advantages and disadvantages of iodine-125 (125I) seed implantation and pancreaticoduodenectomy (PD) in the treatment of pancreatic cancer.MethodsPatients with diagnosed pancreatic cancer who were treated with 125125I seed implantation (30 patients) or PD (30 patients) in our hospital were evaluated for operative time, bleeding, liver function, time to first bowel movement and normal diet, survival, and medical costs.ResultsCompared with patients who underwent PD, those given 125I seed implantation had significantly shorter operative time, less bleeding, higher albumin, shorter periods to bowel movement and normal diet, lower risk of complications, and lower medical costs (P < 0.001, each). The difference of bilirubin level, time to feeding, and median survival were not significant statistically between two treatment grouops.ConclusionFor pancreatic cancer patients for whom PD is not appropriate or who refuse PD, 125I seed implantation is a good option.

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