• World Neurosurg · Jan 2022

    Diagnostic performance of Caprini risk assessment model combined with D-dimer for preoperative deep vein thrombosis in patients with thoracolumbar fractures caused by high-energy injuries.

    • Haiying Wang, Bing Lv, Weifeng Li, Shunyi Wang, and Wenyuan Ding.
    • Department of Orthopaedic Surgery, Baoding No. 1 Central Hospital, Baoding, P.R. China. Electronic address: weishenme68@126.com.
    • World Neurosurg. 2022 Jan 1; 157: e410-e416.

    ObjectiveTo assess the validity of the Caprini risk assessment model (RAM) in risk stratification for deep vein thrombosis (DVT) and to investigate the diagnostic value of Caprini score combined with D-dimer in predicting DVT.MethodsThis study involved 429 patients with thoracolumbar fractures caused by high-energy injuries between October 2016 and November 2019. All patients were treated surgically and had a mean age of 45.3 ± 11.4 years. Patients were risk-stratified using the 2013 Caprini RAM. Mechanical and chemical prophylaxis were used for DVT. Duplex ultrasound of both lower extremities was performed before surgery.ResultsOf the 429 patients, 62 (14.45%) developed DVT. The incidence of preoperative DVT was correlated with Caprini score according to risk stratification(χ2 = 117.4, P < 0.001). Based on the original Caprini RAM, all the patients scored in the highest risk category (score ≥5). Further substratification showed that the majority (277 of 429, 64.57%) of the patients were in the Caprini score range 7-8 and the risk of preoperative DVT was significantly higher among patients with Caprini score >10. The area under the receiver operating characteristic curve of Caprini score and D-dimer was 0.816 and 0.769 when Caprini score >8 or D-dimer >1.81mg/L was considered the criterion of predicting the risk of DVT. When combining the 2 variables, the area under the ROC curve can increase to 0.846.ConclusionsThe Caprini RAM is an effective and reliable DVT risk stratification tool in patients with thoracolumbar fractures caused by high-energy injuries. Caprini score >8 or D-dimer >1.81 mg/L may predict the occurrence of preoperative DVT and the Caprini score combined with D-dimer exhibit better diagnostic performance.Copyright © 2021 Elsevier Inc. All rights reserved.

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