• Rev Assoc Med Bras (1992) · Jun 2021

    Expression of metalloproteinases 2 and 9 and plasma zinc concentrations in women with fibroadenoma.

    • Luana Mota Martins, Igor Sabino Barros, Emanuelle de Sousa Ferreira, Antonio Gomes da Silva Neto, Carla Solange de Melo Escórcio Dourado, Victor Alves de Oliveira, OliveiraAna Raquel Soares deARShttp://orcid.org/0000-0003-4000-7461Universidade Federal do Piauí - Teresina (PI), Brazil., MoraisJennifer Beatriz SilvaJBShttp://orcid.org/0000-0002-9055-7851Universidade Federal do Piauí - Teresina (PI), Brazil., Dilina do Nascimento Marreiro, and Benedito Borges da Silva.
    • Universidade Federal do Piauí - Teresina (PI), Brazil.
    • Rev Assoc Med Bras (1992). 2021 Jun 1; 67 (6): 806-810.

    ObjectiveThis study aims to investigate the association between the immunohistochemical expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and plasma zinc in women with fibroadenoma.MethodsThis cross-sectional study included 37 premenopausal women with fibroadenoma. Waist circumference and body mass index of the participants were measured. Plasma zinc concentrations were determined using atomic flame absorption spectrophotometry. Fragments of breast tissue were fixed and incubated with primary mouse monoclonal antibodies (monoclonal antibodies matrix metalloproteinase -2 -507 and monoclonal antibodies matrix metalloproteinase -9-439). Semi-quantitative analysis of matrix metalloproteinase-2 and matrix metalloproteinase-9 immunoreactivity was performed. Spearman's test and Friedman's test were used for statistical analyses. The p<0.05 were considered statistically significant.ResultsThe average age of the participants was 32.81±9.51 years. The body mass index and waist circumference values were within the normal range. The mean plasma zinc concentration was 42.73±13.84 µg/dL, with 94.6% inadequacy. A statistically significant difference was found between the positive expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 (p=0.0184). There was no significant correlation between the matrix metalloproteinase expression and the plasma zinc levels.ConclusionsWomen with fibroadenoma had hypozincemia and positive expression of metalloproteinases.

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