• Rev Assoc Med Bras (1992) · Jun 2021

    Association between hyperuricemia and hypertension: a case-control study.

    • Talma Tallyane Dantas Bezerra, Lucas Soares Bezerra, Marcelo Antônio Oliveira Santos-Veloso, Andrea Bezerra de Melo da Silveira Lordsleem, and Sandro Gonçalves de Lima.
    • Universidade Federal de Pernambuco, Hospital das Clínicas, Serviço de Cardiologia - Recife (PB), Brazil.
    • Rev Assoc Med Bras (1992). 2021 Jun 1; 67 (6): 828-832.

    ObjectiveThe aim of this study was to evaluate the association between hyperuricemia and systemic arterial hypertension.MethodsThis was a case-control study where individuals aged >18 years were included, who were divided into hypertensive and non-hypertensive groups, excluding those with incomplete information in medical records or with the chronic kidney disease epidemiology collaboration <60 mL/min/1.73 m³. Systemic arterial hypertension was categorized as a dependent variable, while the independent variables were hyperuricemia (i.e., primary variable), sex, education, the practice of physical activity, alcoholism, smoking, diabetes mellitus, chronic kidney disease, a family history of systemic arterial hypertension, age, isolated hyperlipidemia, and mixed hyperlipidemia. Statistical analysis included the univariate and multivariate data analysis, performed by adjusting the logistic regression models using the software R (R Core Team [2018]).ResultsOut of 103 patients evaluated, 75 patients were included in this study. In hypertensive patients, hyperuricemia was more frequent (p=0.029), being present in 18.9% individuals. In the univariate analysis, a statistically significant association was found between hyperuricemia and systemic arterial hypertension (OR 10.9; 95%CI 1.29-1420.0; p=0.023); however, in the multivariate analysis, when adjustment was made for age, the only control variable that persisted in the model, this association ceased to be significant (OR 8.5; 95%CI 0.87-1157.0; p=0.070).ConclusionsThere was no independent association between hyperuricemia and systemic arterial hypertension. The latter was associated with diabetes mellitus, chronic kidney disease, and age.

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