• Lancet neurology · Nov 2021

    Review

    The role of manganese dysregulation in neurological disease: emerging evidence.

    • Dimitri Budinger, Serena Barral, Audrey K S Soo, and Manju A Kurian.
    • Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, University College London, London, UK.
    • Lancet Neurol. 2021 Nov 1; 20 (11): 956-968.

    AbstractManganese is an essential trace metal. The dysregulation of manganese seen in a broad spectrum of neurological disorders reflects its importance in brain development and key neurophysiological processes. Historically, the observation of acquired manganism in miners and people who misuse drugs provided early evidence of brain toxicity related to manganese exposure. The identification of inherited manganese transportopathies, which cause neurodevelopmental and neurodegenerative syndromes, further corroborates the neurotoxic potential of this element. Moreover, manganese dyshomoeostasis is also implicated in Parkinson's disease and other neurodegenerative conditions, such as Alzheimer's disease and Huntington's disease. Ongoing and future research will facilitate the development of better targeted therapeutical strategies than are currently available for manganese-associated neurological disorders.Copyright © 2021 Elsevier Ltd. All rights reserved.

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