• Hoa Le Tuyet, Tram Tran Nguyen Quynh, Hien Vo Hoang Minh, Dao Nguyen Thi Bich, Thang Do Dinh, Duc Le Tan, Hoang Lam Van, Truong Le Huy, Hau Doan Huu, and Tri Nguyen Tran Trong.
• Department of Endocrinology, ChoRay Teaching Hospital, Hochiminh City, Vietnam. letuyethoa@gmail.com
• Int Wound J. 2009 Apr 1; 6 (2): 159-66.

ObjectiveTo evaluate the efficacy and safety of recombinant human epidermal growth factor (rh-EGF) in healing foot ulcers in diabetic patients.MethodsA total of 28 subjects with foot ulcers were recruited into the pilot study. Patients who had obvious peripheral arterial disease, trans-tibial amputation, plastic surgery or skin flap, and skin graft were excluded. The properly debrided wounds and the non closure wounds after toe amputation were included. When the wounds became clean or uninfected, they received twice-a-day treatment with 0.005% Easyef and hydrocolloid dressing. The size and severity of the wounds were evaluated. Others such as blood sugar, renal and hepatic function, serum albumin, vascular condition, foot infection or osteomyelitis were assessed.ResultsAll of 28 patients had positive response of granulation (100%). Complete healing was noted in 13 out of 23 subjects and finished 8-week follow-up (56.5%). The rates of wound closure were 43.3%, 59.9%, 68.7%, and 84.8% in week 2, 4, 6 and 8, respectively, regardless of the severity. Being dropped out, three patients needed further interventions. No skin allergic reaction. Over-granulation was observed in one female patient (3.7%), but as minor.ConclusionsEasyef has positive effects on healing of moderate-to-severe foot ulcers and demonstrated being safe to diabetic patients. The drug had high tolerability and compliance.

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