• Vaccine · Feb 2007

    Randomized Controlled Trial

    Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naïve and vaccinia-immune individuals.

    • Janie Parrino, Lewis H McCurdy, Brenda D Larkin, Ingelise J Gordon, Steven E Rucker, Mary E Enama, Richard A Koup, Mario Roederer, Robert T Bailer, Zoe Moodie, Lin Gu, Lihan Yan, Barney S Graham, and VRC 201/203 Study Team.
    • Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
    • Vaccine. 2007 Feb 9; 25 (8): 1513-25.

    AbstractModified vaccinia Ankara (MVA) was evaluated as an alternative to Dryvax in vaccinia-naïve and vaccinia-immune adult volunteers. Subjects received intramuscular MVA or placebo followed by Dryvax challenge at 3 months. Two or more doses of MVA prior to Dryvax reduced severity of lesion formation, decreased magnitude and duration of viral shedding, and augmented post-Dryvax vaccinia-specific CD8(+) T cell responses and extracellular enveloped virus protein-specific antibody responses. MVA vaccination is safe and immunogenic and improves the safety and immunogenicity of subsequent Dryvax vaccination supporting the potential for using MVA as a vaccine in the general population to improve immunity to orthopoxviruses.

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