• Yao Chen and Guang-Zhi Zhang.
• Edong Healthcare City Hospital of Traditional Chinese Medicine (Infectious Disease Hospital); Ezhou, Hubei, China.
• Medicine (Baltimore). 2021 Oct 22; 100 (42): e27558e27558.

BackgroundChronic pain is a common postsurgery symptom. It has an adverse impact on patients' overall wellbeing. Chronic pain after an operation is caused by intricate mechanisms that have not been well understood. The predictability of most surgical methods has enabled scholars to conduct randomized controlled trials (RCTs) involving pharmacological interventions to prevent chronic pain after a surgery. Therefore, the present study aims to evaluate the curative effects of gabapentin to prevent chronic pain in adults after surgery.MethodsThe authors will collect RCTs related to the use of gabapentin to prevent chronic pain in adults following surgery. Accordingly, a comprehensive search will be performed in 4 online databases to find English language articles, including Cochrane Library, EMBASE, Web of Science, and PubMed. In addition, the search also includes 3 Chinese language databases: VIP data, WanFang database, and China National Knowledge Infrastructure. Each of the RCT published from their inception to September 2021 will be considered. The authors will carry out a meta-analysis of RCTs after screening the studies. Subsequently, the authors will use RevMan (v 5.3) to perform an assessment of bias risk, data synthesis, and subgroup analysis, provided inclusion criteria are met.ResultsThe results will provide clinical evidence for the curative effects of gabapentin to prevent chronic pain in adults after surgery.ConclusionThe summary provided in this systematic review will judge whether gabapentin intervention is effective and feasible to prevent chronic pain in adults following surgery.Registration number: 10.17605/OSF.IO/XG4CK.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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