• Am. J. Hematol. · Aug 2005

    Case Reports

    Therapy-related acute myeloid leukemia after single-agent treatment with fludarabine for chronic lymphocytic leukemia.

    • Clarence C K Lam, Edmond S K Ma, and Yok-Lam Kwong.
    • Department of Pathology, University of Hong Kong, Hong Kong.
    • Am. J. Hematol. 2005 Aug 1; 79 (4): 288-90.

    AbstractA 70-year-old man with B-cell chronic lymphocytic leukemia (CLL) received single-agent treatment with the purine analogue fludarabine, which led to complete remission. After 8 years, he presented with pancytopenia. Marrow examination showed acute myeloid leukemia (AML) with trilineage myelodysplasia (MDS). Cytogenetic analysis showed an unbalanced der(1;7)(p10;q10) that resulted effectively in deletion 7q; confirming the diagnosis of therapy-related AML (t-AML). No residual CLL was present. Together with previous reports of secondary cancers after fludarabine treatment and the association of monosomy 7/7q- with another purine analogue azathioprine, results suggest that t-AML might develop after fludarabine therapy.Copyright (c) 2005 Wiley-Liss, Inc.

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