• Keiseki Kaneyama, Natsuki Segami, Wei Sun, Jun Sato, and Kazuma Fujimura.
• Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Ishikawa-Ken, Japan. k-k@kanazawa-med.ac.jp
• Oral Surg Oral Med O. 2005 Mar 1; 99 (3): 276-84.

ObjectiveTo measure the levels of various cytokines, cytokine receptors, and cytokine antagonists in the synovial fluid of patients with temporomandibular disorders (TMD) and to determine the correlations among these expression levels.Study DesignSynovial fluid was obtained from 55 patients with TMD and from 5 asymptomatic healthy volunteers as controls. The concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, soluble tumor necrosis factor receptors I and II (sTNFR-I and sTNFR-II), IL-6 soluble receptor (IL-6sR), IL-1 soluble receptor type II, and IL-1 receptor antagonist were determined by enzyme-linked immunosorbent assay.ResultsThe concentrations of TNF-alpha, IL-6, IL-1beta, sTNFR-I, and sTNFR-II were significantly higher in the synovial fluid of patients than in controls (P < .05). TNF-alpha level was positively correlated with those of IL-6, sTNFR-I, and sTNFR-II. In particular, there was a highly significant positive correlation between sTNFR-I and sTNFR-II.ConclusionTNF and sTNFRs in the synovial fluid of patients with TMD may be important in the pathogenesis of these disorders.

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