• N. Z. Med. J. · Feb 2012

    Historical Article

    The Cockroft and Gault formula for estimation of creatinine clearance: a friendly deconstruction.

    • J Alasdair Millar.
    • Medical Department, Southland Hospital, Invercargill, New Zealand. Alasdair.millar@health.wa.gov.au
    • N. Z. Med. J. 2012 Feb 24; 125 (1350): 119-22.

    AimsTo review the derivation of the Cockroft and Gault formula for estimating creatinine clearance from serum creatinine in a historical context.MethodThe derivation described by Cockroft and Gault was reviewed, and an alternative formula was sought using the data reported in the paper.ResultsCockroft and Gault used 24 hour urine creatinine data expressed as mg/kg body weight and mathematical manipulation of a linear regression equation which introduced body weight as an independent variable into the formula. This involved a circular logic and may have been mathematically invalid. A more logical equation not containing body weight was derived from the data.ConclusionThe Cockcroft and Gault formula has been validated by long usage but the derivation appears logically insecure. Nevertheless, its role in estimating renal function at the bedside is established.

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