• Ugeskrift for laeger · Jun 2008

    Case Reports

    [Pneumocystis jiroveci pneumonia during infliximab therapy].

    • Maria Eklund Josephson, KristensenLena HagelskjaerLH, and Vibeke Charlotte Andersen.
    • Regionshospitalet Viborg, Medicinsk Afdeling, Viborg.
    • Ugeskr. Laeg. 2008 Jun 9; 170 (24): 2159-60.

    AbstractThe treatment of ulcerative colitis has improved since the appearance of Tumor Necrosis Factor (TNF)-alpha inhibitors. However, the use of TNF-alpha inhibitors increases the risk of opportunistic infections. We describe two cases of Pneumocystis jiroveci pneumonia during infliximab therapy for active ulcerative colitis. They were successfully treated with sulfametoxazole/trimetroprim. High awareness of P. jiroveci pneumonia in patients who develop pulmonary symptoms with hypoxia during TNF-alpha modulator therapy is recommended.

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