• Mahmut Sami Metin, Handan Bilen, Ömer Faruk Elmas, and Necmettin Akdeniz.
• Department of Dermatology, Faculty of Medicine, Kırşehir Ahi Evran University, Kırşehir, Turkey.
• Turk J Med Sci. 2021 Dec 13; 51 (6): 301730213017-3021.

Background/AimHuman HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is a gene that is extensively expressed in human tissues as well as in tumor tissues. This study aimed to explore the potential role of HTATIP2/TIP30 in contact dermatitis (CD), which is one of the most common inflammatory cutaneous conditions.Materials And MethodsThis cross-sectional study involved adult patients with acute contact dermatitis who were admitted to the outpatient dermatology clinic of a tertiary hospital and healthy adult volunteers without any cutaneous or systemic diseases. The blood concentration of HTATIP2/TIP30 was measured using ELISA kits.ResultsThe research sample consisted of 31 patients with CD (18 males, 13 females) and 20 healthy control subjects (14 males, 6 females). The mean ages of the patients with CD and healthy volunteers were 37 and 30 years, respectively (p > 0.05). The mean value of serum HTATIP2/TIP30 levels in patients with CD was 1.65 ng ml–1, which is 0.60 ng ml–1 in the control group (p = 0.02)ConclusionIn this study, serum levels of HTATIP2/TIP30 were statistically significantly higher in patients with CD when compared to healthy controls. This outcome may indicate possible role of HTATIP2/TIP30 in the pathogenesis of CD.This work is licensed under a Creative Commons Attribution 4.0 International License.

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