• BMJ case reports · Apr 2016

    Case Reports

    Dysphagia and anorexia as presentations of leptomeningeal carcinomatosis.

    • Rohit Aiyer, Ester Engelman, Wei Xue, and Edward Yu.
    • Department of Psychiatry, Hofstra Northwell Health-Staten Island University Hospital, Staten Island, New York, USA.
    • BMJ Case Rep. 2016 Apr 12; 2016.

    AbstractA 61-year-old woman presented to the emergency department, with a 4-day history of isolated oropharyngeal dysphagia associated with anorexia and weight loss over the previous 4 weeks. She had no other focal neurological symptoms and no deficits on examination. She had been in a 4-year remission of breast cancer postmastectomy and chemoradiation. Neuroimaging showed enhancement of cranial nerves VII, VIII, cisternal segment of cranial V, dorsal and ventral surfaces of the cervical and thoracic cord as well as enhancement of the cauda equina. Cerebrospinal fluid analysis revealed carcinomatous cells. The patient was diagnosed as having leptomeningeal carcinomatosis secondary to lobular breast cancer and was started on radiation therapy, antihormonal treatments and intrathecal methotrexate.2016 BMJ Publishing Group Ltd.

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