• Mireia Adelantado-Renau, David Jiménez-Pavón, Maria Reyes Beltran-Valls, Jesús Gustavo Ponce-González, Óscar Chiva-Bartoll, and Diego Moliner-Urdiales.
• LIFE Research Group, University Jaume I, Av. de Vicent Sos Baynat, s/n, 12071, Castellon, Spain.
• Eur. J. Pediatr. 2018 Oct 1; 177 (10): 1555-1563.

AbstractWe tested the mediating effect of leptin on the association between physical fitness (PF) components and academic performance indicators in healthy adolescents. A total of 263 adolescents (13.9 ± 0.3 years, 47.5% girls, 12.5% overweight) from the DADOS (Deporte, ADOlescencia y Salud) Study were included in the analysis. PF components were assessed by the handgrip test for upper-limb muscular strength, standing long jump test for lower-limb muscular strength, 4 × 10-m shuttle run test for speed-agility, and 20-m shuttle run test for cardiorespiratory fitness. Plasma leptin concentration was assessed from antecubital vein blood after an overnight fast using a sensitive ELISA kit. Academic performance indicators were assessed through final school grades and through the Spanish version of the SRA Test of Educational Ability. Body composition was assessed by body mass index and skinfold thicknesses. Boot-strapped mediation procedures were performed and indirect effects with confidence intervals not including zero were interpreted as statistically significant. Our findings suggest that the positive associations observed between cardiorespiratory fitness and lower-limb muscular strength with academic performance indicators were mediated by leptin concentration after adjusting for sex, pubertal stage, socioeconomic status, and adiposity (percentage of mediation ranging from 54.61 to 82.02%).

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