• J Comput Assist Tomogr · Nov 2008

    Dynamic contrast-enhanced derived cerebral blood volume correlates better with leak correction than with no correction for vascular endothelial growth factor, microvascular density, and grading of astrocytoma.

    • Mohammad Haris, Nuzhat Husain, Anup Singh, Mazhar Husain, Savita Srivastava, Chhitiz Srivastava, Sanjay Behari, Ram Kishore S Rathore, Sona Saksena, and Rakesh Kumar Gupta.
    • Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
    • J Comput Assist Tomogr. 2008 Nov 1; 32 (6): 955-65.

    ObjectiveTo look for the impact of leak correction on correlation of perfusion indices with microvessel density (MVD) and vascular endothelial growth factor (VEGF) in astrocytomas.MethodsDynamic contrast-enhanced magnetic resonance imaging was performed in 64 patients with varying grades of astrocytoma. Perfusion indices (ie, relative cerebral blood volume (rCBV) with and without leak correction, relative cerebral blood flow (rCBF), permeability (k(trans)), and leakage (v(e)) were quantified. MVD and VEGF-expressing cells were quantified from the excised tumor tissues and were correlated with perfusion metrics.ResultsPerfusion indices showed significant difference among the astrocytoma grades. The corrected rCBV correlated better with MVD and VEGF. The corrected rCBV correlated (r = 0.853, P = <0.001) strongly, whereas the uncorrected rCBV (r = 0.592, P = <0.001) and k(trans) (r = 0.498, P = 0.001) correlated moderately with tumor grade. The corrected rCBV discriminated 100% low-grade from high-grade astrocytoma, while uncorrected rCBV did this in 95.5% low-grade and 71.4% high-grade astrocytoma.ConclusionsCorrected rCBV better correlates with grade and is more accurate in discriminating low-grade from high-grade astrocytoma compared with uncorrected rCBV.

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