• Michael Baroody, Morris E Hartstein, and John B Holds.
• Pennsylvannia State University, Department of Surgery, USA.
• Ophthal Plast Reconstr Surg. 2003 Jul 1; 19 (4): 270-4.

PurposeTo present 3 cases of melanoma metastatic to the orbit treated with various traditional modalities including surgery and chemotherapy and being treated with melanoma vaccines and to present background information on immunotherapy.MethodsRetrospective review of 3 patients with melanoma metastatic to the orbit who were treated with melanoma vaccines along with conventional treatments. One patient had known orbital involvement before vaccine treatment; 2 patients had orbital metastases subsequent to vaccine administration.ResultsPatients survived at least 13 months after the diagnosis of metastatic melanoma, with 1 patient surviving 51 months after the onset of metastases and administration of melanoma vaccine.ConclusionsAlthough still unproven, immunotherapy with melanoma vaccines is a promising new treatment modality for metastatic melanoma with few side effects.

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