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J. Neurol. Neurosurg. Psychiatr. · Jun 2011
Case ReportsAttention deficits following ADEM ameliorated by guanfacine.
- Victoria Singh-Curry, Paresh Malhotra, Simon F Farmer, and Masud Husain.
- UCL Institute of Cognitive Neuroscience, 17 Queen Square, London, WC1N 3AR, UK.
- J. Neurol. Neurosurg. Psychiatr. 2011 Jun 1; 82 (6): 688-90.
AbstractThe authors report here the case of a patient with severe deficits in arousal and sustained attention, associated with hemispatial neglect. These impairments were secondary to acute disseminated encephalomyelitis, with bilateral involvement of the medial nuclei and pulvinar of the thalamus. Treatment with the noradrenergic agonist guanfacine, previously used for attention deficits in attention deficit/hyperactivity disorder and stroke, was associated with a significant amelioration of both the spatial and sustained attention impairments in neglect. Guanfacine may prove to be a useful tool in the treatment of disorders of attention associated with neurological conditions.
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