• Pasiri Sithinamsuwan, Kunchit Piyavechviratana, Thitisak Kitthaweesin, Watcharapong Chusri, Patima Orrawanhanothai, Adisorn Wongsa, Anan Wattanathum, Yotin Chinvarun, Samart Nidhinandana, Bancha Satirapoj, Ouppatham Supasyndh, Chantrapa Sriswasdi, Wichai Prayoonwiwat, and Phramongkutklao Army Hospital Exertional Heatstroke Study Team.
• Division of Neurology, Department of Medicine, Phramongkutklao Army Hospital and Medical College, Bangkok, 10400, Thailand.
• Mil Med. 2009 May 1;174(5):496-502.

ObjectiveTo determine the clinical outcomes of an aggressive combined cooling technique for exertional heatstroke in Thailand.MethodsWe analyzed patients who were diagnosed with exertional heatstroke between 1995 and 2007. Outcomes were assessed both in hospital and at 3 months follow-up.ResultsTwenty-eight cases of exertional heatstroke presented to Phramongkutklao Army Hospital over 12 years. All patients developed multiorgan dysfunction and encephalopathy. Twenty-four cases had acute renal failure, 7 of whom required dialysis. Disseminated intravascular coagulation (DIC) was detected in 9 patients (32.1%). In-hospital mortality was 7.1%. Most survivors recovered with nearly normal organ function. However, 9 exhibited prolonged neurologic dysfunction and 2 had chronic renal dysfunction requiring hemodialysis. At 3-month follow-up, neurologic and renal dysfunction in those patients persisted. Higher serum prothrombin time and DIC correlated to fatality. The patients whose core body temperature achieved 38 degrees C within 3 hours revealed a significantly lower DIC and twice as low in the frequency of poor outcome than the patients cooled longer than 3 hours to reduce core body temperature to 38 degrees C.ConclusionsDespite early recognition and aggressive combined cooling, exertional heatstroke remains associated with multiorgan dysfunction. However, our 7.1% in-hospital mortality rate was low compared to previous studies. Early diagnosis and prompt treatment are critical.

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