• J Clin Neurosci · Nov 2014

    Review Case Reports

    Dural-based Rosai-Dorfman disease: differential diagnostic considerations.

    • Richard A Prayson and J Jordi Rowe.
    • Cleveland Clinic, Department of Pathology, L25, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: praysor@ccf.org.
    • J Clin Neurosci. 2014 Nov 1; 21 (11): 1872-3.

    AbstractExtranodal sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a non-neoplastic condition that has rarely been reported to involve the central nervous system. This report documents a 28-year-old man with Rosai-Dorfman disease who presented with a seizure and a dural-based mass that was thought to represent a meningioma. Resection showed a lesion marked by large, S-100 protein immunoreactive histiocytic cells with intermixed benign lymphocytes and plasma cells. Emperipolesis with intracytoplasmic lymphocytes and plasma cells was present. Differential diagnostic considerations will be discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

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