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- Xiao-shan Liu, Jikai Jiang, Xiao-yang Jiao, Ying-e Wu, Jing-hua Lin, and Ying-mu Cai.
- Center for Molecular Biology, School of Medicine, Shantou University, Shantou 515031, China. xsliu@stu.edu.cn
- Cancer Lett. 2009 Feb 8; 274 (1): 16-24.
AbstractLycorine is an alkaloid isolated from the bulb of the Amaryllidaceae Lycoris. Here, we report that treatment with lycorine resulted in survival inhibition and apoptosis induction in human leukemia cell lines. Lycorine induced apoptosis in human leukemia cells via intrinsic mitochondria pathway and caused a rapid-turnover of protein level of Mcl-1 which occurred before caspases activation. Furthermore, pronounced apoptosis accompanied by the down-regulation of Mcl-1 was also observed in blasts from patients with acute myeloid leukemia. Our findings suggest that lycorine may be a good candidate therapeutic agent against leukemia in worth of further evaluation.
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